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Utilizing the GCRLE grant, Munakata and Namekawa will glimpse far more carefully at how oocytes are genomically primed and saved for later use. They can examine the job of a chromatin remodeler in oocyte survival and fertility.
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By the time a human feminine is born, her establishing ovaries by now comprise all of the egg cells, or “oocytes,” that she will ovulate over the course of her reproductive lifestyle.
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Namekawa believes that in human oocytes, alterations in these patterns could disrupt the delicate choreography of genes staying turned on and off at the proper periods — leaving them unprepared for fertilization or growth into healthier embryos. Variations in chromatin construction being an oocyte ages may also influence the best way that chromosomes segregate all here through cell division.
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